We just released a step-by-step procedure to replace original Dual Core Xeon CPUs of a Mac Pro 3.0GHz by Quad Core Xeon X5355 CPUs clocked at 2.66GHz.
As shown below, OSX perfectly handles doubled number of cores:
Direct link to the article: http://www.hardmac.com/articles/70/
A future article will evaluate performance gain obtained by doubling core number.
PS: Thank to Intel for giving us the opportunity to "play" with their last Quad Core Xeon CPU.